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Molindone (Systemic)

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Molindone (Systemic)

US Brand Names

• Moban

• Moban Concentrate


Molindone (moe-LIN-done) is used to treat nervous, mental, and emotional conditions.

Molindone is available only with your doctor's prescription, in the following dosage forms:


    • Solution (U.S.)

    • Tablets (U.S.)

Special Considerations

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For molindone, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to molindone, phenothiazines, thioxanthenes, haloperidol, or loxapine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.


Molindone has not been shown to cause birth defects or other problems in humans. However, studies in mice have shown a slight decrease in successful pregnancies.


It is not known if molindone passes into breast milk.


Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of molindone in children with use in other age groups.

Older adults

Elderly patients are usually more sensitive than younger adults to the effects of molindone. Constipation, dizziness or lightheadedness, drowsiness, dryness of mouth, trembling of the hands and fingers, and symptoms of tardive dyskinesia (such as rapid, worm-like movements of the tongue or any other uncontrolled movements of the mouth, tongue, or jaw, and/or arms and legs) are especially likely to occur in elderly patients.

Other medicines

Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking molindone, it is especially important that your health care professional know if you are taking any of the following:

    • Amoxapine (e.g., Asendin) or

    • Methyldopa (e.g., Aldomet) or

    • Metoclopramide (e.g., Reglan) or

    • Metyrosine (e.g., Demser) or

    • Other antipsychotics (medicine for mental illness) or

    • Pemoline (e.g., Cylert) or

    • Pimozide (e.g., Orap) or

    • Promethazine (e.g., Phenergan) or

    • Rauwolfia alkaloids (alseroxylon [e.g., Rauwiloid], deserpidine [e.g., Harmonyl], rauwolfia serpentina [e.g., Raudixin], reserpine [e.g., Serpasil]) or

    • Trimeprazine (e.g., Temaril)-Taking these medicines with molindone may increase the chance and seriousness of some side effects

    • Central nervous system (CNS) depressants (medicine that causes drowsiness) or

    • Tricyclic antidepressants (medicine for depression)-Taking these medicines with molindone may increase the CNS depressant effects

    • Lithium (e.g., Eskalith, Lithane)-The chance of serious side effects may be increased

Other medical problems

The presence of other medical problems may affect the use of molindone. Make sure you tell your doctor if you have any other medical problems, especially:

    • Brain tumor or

    • Intestinal blockage-Molindone may interfere with the diagnosis of these conditions

    • Difficult urination or

    • Enlarged prostate or

    • Glaucoma or

    • Liver disease or

    • Parkinson's disease-Molindone may make the condition worse


Molindone should be taken with food or a full glass (8 ounces) of water or milk to reduce stomach irritation.

The liquid form of molindone may be taken undiluted or mixed with milk, water, fruit juice, or carbonated beverages.

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sometimes this medicine must be taken for several weeks before its full effect is reached in the treatment of certain mental and emotional conditions .


The dose of molindone will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of molindone. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets or amount of solution that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using molindone .

    • For oral dosage forms (solution or tablets):

      o Adults: To start, 50 to 75 milligrams a day, taken in smaller doses three or four times during the day. For maintenance, the dose you take will depend on your condition and may be from 15 to 225 milligrams a day, taken in smaller doses three or four times during the day.

      o Children up to 12 years of age: The dose must be determined by the doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


To store this medicine:

    • Keep out of the reach of children.

    • Store away from heat and direct light.

    • Do not store the tablets in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.

    • Keep the liquid form of this medicine from freezing.

    • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.


Your doctor should check your progress at regular visits. This will allow the dosage of the medicine to be adjusted when necessary and also will reduce the possibility of side effects.

Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

Do not take molindone within 1 or 2 hours of taking antacids or medicine for diarrhea . Taking them too close together may make molindone less effective.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine .

Molindone may cause some people to become drowsy or less alert than they are normally, especially during the first few weeks the medicine is being taken. Even if you take this medicine only at bedtime, you may feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert .

Dizziness or lightheadedness may occur , especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

These medicines may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke . Also, hot baths or saunas may make you feel dizzy or faint while you are taking this medicine.

Molindone may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infection.

Side Effects

Along with its needed effects, molindone can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Symptoms of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it .

Stop taking molindone and get emergency help immediately if any of the following side effects occur:


Convulsions (seizures); difficult or fast breathing; fast heartbeat or irregular pulse; fever (high); high or low (irregular) blood pressure; increased sweating; loss of bladder control; muscle stiffness (severe); unusually pale skin; unusual tiredness or weakness.

Also, check with your doctor as soon as possible if any of the following side effects occur:

More common

Difficulty in talking or swallowing; inability to move eyes; lip smacking or puckering; loss of balance control; mask-like face; muscle spasms, especially of the neck and back; puffing of cheeks; rapid or worm-like movements of tongue; restlessness or need to keep moving (severe); shuffling walk; stiffness of arms and legs; trembling and shaking of hands; twisting movements of body; uncontrolled movements of arms and legs; unusual chewing movements.

Less common

Mental depression.


Confusion; hot, dry skin, or lack of sweating; muscle weakness; skin rash; yellow eyes or skin.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Blurred vision; constipation; decreased sweating; difficult urination; dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position; drowsiness; dryness of mouth; headache; nausea; stuffy nose.

Less common

Changes in menstrual periods; decreased sexual ability; false sense of well-being; swelling of breasts; unusual secretion of milk.

Some side effects may occur after you have stopped taking this medicine. Check with your doctor as soon as possible if you notice any of the following effects:

Lip smacking or puckering; puffing of cheeks; rapid or worm-like movements of tongue; uncontrolled chewing movements; uncontrolled movements of arms and legs.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

November 19, 1998

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